| Acid Chlorides |
Ethylene oxide |
Oxidations |
| Acylations |
Eliminations |
Oxynitrilases |
| Alcoholysis |
Enzymatic chemistry |
|
| Alcohol Dehydrogenases (ADH) |
Epichlorohydrine |
Peptide Couplings (T3P, Trichloroacetic anhydride) |
| Alkoxylations |
Esterification |
Phase transfer catalysis |
| Alkali Metals |
Ethoxylations |
Phenylpyridines |
| Alkylations |
|
Phosgenation (Triphosgene) |
| Amidations |
|
Piperazines |
| Aminations |
Fluoroaromatics |
Pyridines |
| Antihypertensives |
Fluoronucleosides |
|
| Antivirals |
Fraction Distillation of High Melting Solids |
Quinolones, Quinolines, Quinoxalines |
| Aryl Piperazines |
Friedel Crafts Reactions |
|
|
Furanes |
Racemate Resolution |
| Biocatalysis |
|
Reductions |
| Biphenyls, Biaryls |
Glutaric Acid Derivatives |
Reductive Amination |
| Borontrifluoride Catalyzed Reactions |
Grignard Reactions |
|
| Borane Reductions |
Grignard Formation via Halogen Exchange |
Saponifications |
| Boronic Acids (aromatic, aliphatic, heterocyclic) |
|
Sterile Ultrafiltration |
| Brominations |
Halogenations (chlorine, iodine, bromine, fluorine) |
Sodium Borohydride Handling |
| Butyllithium Handling |
Heterocycles |
Spray Drying Facilities |
|
Hexyl Lithium Handling |
Sterile Bulk Drugs |
| Carboxylation |
High Pressure (ammonia) |
Sulfonations |
| Carboxylic Acid Derivatizations |
High Temperature |
|
| C-C Coupling (Suzuki, Kumada) |
Hydrazine Handling |
TiCl4 |
| C-N Coupling |
Hydride Handling |
Thiophenes |
| C-O Coupling |
Hydrogenation (up to 80 bar) |
Triphosgene Handling |
|
|
|
| Chiral Cyanohydrines |
Indoles |
Ullmann Reactions |
| Chiral Hydrogenation |
|
|
| Chiral Synthesis |
|
Vacuum Distillation |
| Chlorinated Solvents Handling |
|
Veterinary API’s |
| Chlorination |
Lipases |
Vilsmeier |
|
Lithium |
Vitride Handling |
| Chloronicotinic Acid and Derivatives |
Lithium Aluminum Hydride |
|
| Chlorosulfonations |
Low Temperature Reactions
(-100 °C) |
Wiped-film distillation |
| Condensations |
|
Wittig/Wittig-Horner and Reagents |
| Cryogenic Reactions (-100 °C) |
Mannich Reactions |
|
| Cyanation and Cyanide Handling |
Melt Crystallization |
|
| Cyclopentadiene Handling |
Metallocenes |
|
|
Milling (Mixing, Drying) |
|
| Dealkylations |
|
|
| Dehalogenations |
Naphthyridines |
|
| Diazo Chemistry (Sandmeyer) |
Nicotinic Acid Derivatives |
|
| Diels-Alder Reactions |
Nitrations |
|
| Diketene |
N-Oxidations |
|
| |
Nucleosides and Sugars
(Anti-HIV APIs) |
|
| Distillation Under Pressure |
|
|
| Distillation of High Melting Solids |
Optical Resolutions |
|
| Dimethylsulfate |
Organometallics |
|
