About Archimica
We provide quality products and services, consistently,
reliably responsibly and continuously applying some of the
world’s most difficult to handle chemical technologies.
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Our independent one-site, single entity corporate setup enables
Fast, direct
decisions
Simple, direct
decider access
Easiness to deal
with
Focus on customers
and business
History Lodi Site
1947
Foundation of Istituto Chemioterapico Italiano (I.C.I.)
1984
Foundation of Prime European Therapeuticals S.p.A (Euticals)
2008
Mandarin Capital Partners becomes majority Euticals shareholder
2012
Clessidra, an Italian Financial Fund becomes majority Euticals shareholder
2016
AMRI acquired Euticals Group
2019
Effective August 1, Livia acquires Lodi site, and brands it Archimica S.p.A.
Products
Own products (APIs) for the generic pharmaceutical industry.
Synthesis: Manufacturing services and products for all user industries,
using Archimica´s highly differentiated setup and technologies
APIs, Building blocks, GMP intermediates
For all global markets including the United States of America,
in total Archimica products reach 25 countries.
API - Active Pharmaceutical Ingredient Products
- Cytarabine
- Glycerophosphoryl-Choline (GPC)
- Glycerophosphorylethanolamine (GPE)
- Hydroxyurea
- Mianserin Hydrochloride
- Oxcarbazepine
- Pyridine/Sulfur Trioxide
- Sucralfate
- Sucrose Octasulfate Sodium/Potassium salt
- Sulfathiazole
- Amtolmetin Guacil
- Aurothiomalate Sodium
- Azanidazole
- Bromfenac
- Capecitabine
- Citicoline
- Diacereine
- Dihydralazine sulfate
- Disopyramide
- Fludarabine
- Hydralazine hydrochloride
- Iodocasein
- Lithium Carbonate
- Pentetrazole
- Pirenzepine Dihydrochloride
- Sulfapyridine
- Sulthiame
- Thenfadil
- Tolmetin
- Vidarabine
Technologies & Plant
Staff
64%
PRODUCTION
17%
QUALITY
12%
INFRASTRUCTURE
7%
BUSINESS & ADMINISTRATION
Plant
Equipment overview
Reactor Capacity: About 250 m3 (stainless steel and glass line).
Temperature Range: -20 to 150°.
Pressure Range: 10 mbar to 5 bar.
Reactor/Vessel Volume Range: 50 to 10.000 liter.
Dryers: Fluid bed dryer, agitated vacuum pan dryer, vacuum horizontal agitated dryer, vacuum double cone dryer, Planex® dryer, tray dryer.
Centrifuges: Vertical axis top discharge centrifuges, vertical axis bottom discharge centrifuges, horizontal axis peeler centrifuges.
Ancillary Equipment: Filter Press, Sieves, Filters, Ultra Filters.
Products plant list
F1 – QC Laboratory
F2A – Multi-Purpose Plant
F3A – Raw Materials, Intermediates and APIs warehouse
F3B – Finishing & Drying Plant (ISO 8, controlled environment)
F5A – Hydroxyurea Plant
F5B – Multi-Purpose Plant
F5C – Cytarabine Plant
F6A – Sucralfate Plant
F6B – Sulfamidics Plant
F7 – Multi-Purpose Plant
F8 – Utilities
Tech
Main differentiators
Highly flexible and broad permit for all technologies, reagents and solvents.
Broad range of extraordinary hazardous chemistry and chemicals processable in large scale:
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solvents, including chlorinated and toxic solvents;
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Strong acids including phosphorous oxychloride, chlorosulfonicacid, hydrofluoric acid;
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Highly flammable, highly corrosive, explosive chemicals.
Residual thermal oxidizer allowing trace gas contamination removal, all waste gas streams.
Seveso guideline compliant.
Own on-site waste water treatment, backed by external partners.
Solvent recovery and tank farms.
Differentiators - Technology specialities
Large Scale Deacylated Phospholipids production (GPC, GPE)
Large Scale Use of Pyridine as reagent or solvent, as well as pyridine-SO3 complex handling.
Cytostatics manufacturing/drying: Nucleosides.
Heterocyclic chemistry: Pyridines, Piperazines, Quinoxalines, Quinolones, Quinazolinones, Benzofuranes.
Chromatographic purification with ionic resins.
Micronization (third party partners).
Differentiators - Reagents & Solvents
Chlorosulfonic acid
Sulfur trioxide
Pyridine
Ethylene oxide
Triphosgene
Hydrazine, Azides, Diphenyl-phosphorylazide, Acetyl Nitrate
Halogen chemistry:
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Fluorine, chlorine, bromine, iodine
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Hydrofluoric acid
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Chlorine, chlorinating agents
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Bromine, brominating agents (NBS, dibromohydantoin, phosphorous bromides)
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Methylene diiodide, methyliodide, iodoform, TMSOZ
Quality model
API Registration Form: AMA -26/2015
GMP Certificate: NBF/10/2015V
US-FDA
Last inspection April 2017
AIFA
Last Inspection July 2017
KFDA
Last inspection October 2011
Ministry of Health Veterinary
Last periodic inspection June 2019
News
Discover our latest news and articles about
products, research and services.
Archimica Press Release Laboratory Expansion May 2021
25 May 2021 Archimica invests 1,3 Mio. Euro in Expansion of Process Development Capacity Archimica has started the operation of its expanded development laboratories at its Lodi (Italy) site. ARead more
L-α-Glycerophosphoryl-ethanolamine (GPE)
L-α-Glycerophosphoryl-ethanolamine (GPE) is a precursor of neurotransmitters located in the lipid membranes of cells. Scientific studies show that modifications of these membranes are contributing factors in disease or age-related memoryRead more
OXCARBAZEPINE API
Oxcarbazepine is an important drug in treatment of epilepsy and related disorders. It is successfully applied to patients globally in a wide variety of presentations. Recent more stringent quality requirementsRead more
Contacts
GPS coordinates
Latitude: 45 °19’ 25,3“ N
Longitude: 9°27’ 57,7’’ E
The site is located in Northern Italy in Lombardia about 30 km South of Milano and Linate airport. Access to the facility is the motorway A1 Milano-Bologna and the route SS9 Via Emilia.
Site address
Viale Milano 86,
26900 Lodi (LO) Italy
Phone: +39 0371 49021
Fax: +39 0371 610019
Email: contact@archimica.com
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