About Archimica

We provide quality products and services, consistently,
reliably responsibly and continuously
applying some of the
world’s most difficult to handle chemical technologies.

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Our independent one-site, single entity corporate setup enables

Fast, direct

Simple, direct
decider access

Easiness to deal

Focus on customers
and business

History Lodi Site

Foundation of Istituto Chemioterapico Italiano (I.C.I.)

Foundation of Prime European Therapeuticals S.p.A (Euticals)

Mandarin Capital Partners becomes majority Euticals shareholder

Clessidra, an Italian Financial Fund becomes majority Euticals shareholder

AMRI acquired Euticals Group

Effective August 1, Livia acquires Lodi site, and brands it Archimica S.p.A.

Archimica Plant Lodi


Own products (APIs) for the generic pharmaceutical industry.
Synthesis: Manufacturing services and products for all user industries,
using Archimica´s highly differentiated setup and technologies

APIs, Building blocks, GMP intermediates

For all global markets including the United States of America,
in total Archimica products reach 25 countries.

API - Active Pharmaceutical Ingredient Products

  • Cytarabine
  • Glycerophosphoryl-Choline (GPC)
  • Glycerophosphorylethanolamine (GPE)
  • Hydroxyurea
  • Mianserin Hydrochloride
  • Oxcarbazepine
  • Pyridine/Sulfur Trioxide
  • Sucralfate
  • Sucrose Octasulfate Sodium/Potassium salt
  • Sulfathiazole
  • Amtolmetin Guacil
  • Aurothiomalate Sodium
  • Azanidazole
  • Bromfenac
  • Capecitabine
  • Citicoline
  • Diacereine
  • Dihydralazine sulfate
  • Disopyramide
  • Fludarabine
  • Hydralazine hydrochloride
  • Iodocasein
  • Lithium Carbonate
  • Pentetrazole
  • Pirenzepine Dihydrochloride
  • Sulfapyridine
  • Sulthiame
  • Thenfadil
  • Tolmetin
  • Vidarabine

We appreciate your interest in Archimica.
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contact us

Technologies & Plant











Equipment overview

Reactor Capacity: About 250 m3 (stainless steel and glass line).
Temperature Range: -20 to 150°.
Pressure Range: 10 mbar to 5 bar.
Reactor/Vessel Volume Range: 50 to 10.000 liter.
Dryers: Fluid bed dryer, agitated vacuum pan dryer, vacuum horizontal agitated dryer, vacuum double cone dryer, Planex® dryer, tray dryer.
Centrifuges: Vertical axis top discharge centrifuges, vertical axis bottom discharge centrifuges, horizontal axis peeler centrifuges.
Ancillary Equipment: Filter Press, Sieves, Filters, Ultra Filters.

Products plant list

F1 – QC Laboratory
F2A – Multi-Purpose Plant
F3A – Raw Materials, Intermediates and APIs warehouse
F3B – Finishing & Drying Plant (ISO 8, controlled environment)
F5A – Hydroxyurea Plant
F5B – Multi-Purpose Plant
F5C – Cytarabine Plant
F6A – Sucralfate Plant
F6B – Sulfamidics Plant
F7 – Multi-Purpose Plant
F8 – Utilities


Main differentiators

Highly flexible and broad permit for all technologies, reagents and solvents.
Broad range of extraordinary hazardous chemistry and chemicals processable in large scale:

  • solvents, including chlorinated and toxic solvents;

  • Strong acids including phosphorous oxychloride, chlorosulfonicacid, hydrofluoric acid;

  • Highly flammable, highly corrosive, explosive chemicals.

Residual thermal oxidizer allowing trace gas contamination removal, all waste gas streams.
Seveso guideline compliant.
Own on-site waste water treatment, backed by external partners.
Solvent recovery and tank farms.

Differentiators - Technology specialities

Large Scale Deacylated Phospholipids production (GPC, GPE)
Large Scale Use of Pyridine as reagent or solvent, as well as pyridine-SO3 complex handling.
Cytostatics manufacturing/drying:
Heterocyclic chemistry: Pyridines, Piperazines, Quinoxalines, Quinolones, Quinazolinones, Benzofuranes.
Chromatographic purification with ionic resins.
Micronization (third party partners).

Differentiators - Reagents & Solvents

Chlorosulfonic acid
Sulfur trioxide
Ethylene oxide
Hydrazine, Azides, Diphenyl-phosphorylazide, Acetyl Nitrate
Halogen chemistry:

  • Fluorine, chlorine, bromine, iodine

  • Hydrofluoric acid

  • Chlorine, chlorinating agents

  • Bromine, brominating agents (NBS, dibromohydantoin, phosphorous bromides)

  • Methylene diiodide, methyliodide, iodoform, TMSOZ

Quality model

API Registration Form: AMA -26/2015
GMP Certificate: NBF/10/2015V

Last inspection April 2017

Last Inspection July 2017

Last inspection October 2011

Ministry of Health Veterinary
Last periodic inspection June 2019


Discover our latest news and articles about
products, research and services.

  • We Are Hiring

    Send Us the resume CV: contact@archimica.com
    Read more
  • Archimica Press Release Laboratory Expansion May 2021

    25 May 2021 Archimica invests 1,3 Mio. Euro in Expansion of Process Development Capacity Archimica has started the operation of its expanded development laboratories at its Lodi (Italy) site. A
    Read more
  • L-α-Glycerophosphoryl-ethanolamine (GPE)

    L-α-Glycerophosphoryl-ethanolamine (GPE) is a precursor of neurotransmitters located in the lipid membranes of cells. Scientific studies show that modifications of these membranes are contributing factors in disease or age-related memory
    Read more
  • We are hiring

    We Are Hiring

    Send Us the resume CV: contact@archimica.com
    Read more

    Oxcarbazepine is an important drug in treatment of epilepsy and related disorders. It is successfully applied to patients globally in a wide variety of presentations. Recent more stringent quality requirements
    Read more


GPS coordinates
Latitude: 45 °19’ 25,3“ N
Longitude: 9°27’ 57,7’’ E

The site is located in Northern Italy in Lombardia about 30 km South of Milano and Linate airport. Access to the facility is the motorway A1 Milano-Bologna and the route SS9 Via Emilia.

Site address
Viale Milano 86,
26900 Lodi (LO) Italy

Phone: +39 0371 49021
Fax: +39 0371 610019
Email: contact@archimica.com

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For any inquiries please contact us


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