Reactor Capacity Supported by a Vast Range of Sophisticated Ancillary Technology:

Reactor Volume: About 250 m3 (stainless steel and glass line).
Temperature Range: -20 to 160°.
Pressure Range: 10 mbar to 6 bar.
Reactor Volume Range: 50 to 10.000 liters.
Dryers: Fluid bed dryer, agitated vacuum pan dryer, vacuum horizontal agitated dryer, vacuum double cone dryer, Planex® dryer, tray dryer.
Centrifuges/Filters
Filters: Filter Presses – Filter Dryers – Pressure Filters
Centrifuges: Vertical Axis top discharge, Vertical Axis Bottom Discharge, Horizontal Axis Peeler.
Ancillary Equipment: Sieves – Ultra Filters, Ion Exchange Chromatography Columns.

F1 – QC Laboratory
F2A – Multi-Purpose Plant
F3A – Raw Materials, Intermediates and APIs warehouse
F3B – Finishing & Drying Plant (ISO 8, controlled environment)
F5A – Hydroxyurea Plant
F5B – Multi-Purpose Plant
F5C – Cytarabine Plant
F6A – Sucralfate Plant
F6B – Sulfamidics Plant
F7 – Multi-Purpose Plant
F8 – Utilities

Highly flexible and broad permit for all technologies, reagents and solvents.
Broad range of extraordinary hazardous chemistry and chemicals processable in large scale:
solvents, including chlorinated and toxic solvents;
Strong acids including phosphorous oxychloride, chlorosulfonicacid, hydrofluoric acid;
Highly flammable, highly corrosive, explosive chemicals.
Residual thermal oxidizer allowing trace gas contamination removal, all waste gas streams.
Seveso guideline compliant.
Own on-site waste water treatment, backed by external partners.
Solvent recovery and tank farms.

Large Scale Deacylated Phospholipids production (GPC, GPE)
Large Scale Use of Pyridine as reagent or solvent, as well as pyridine-SO3 complex handling.
Cytostatics manufacturing/drying: Nucleosides.
Heterocyclic chemistry: Pyridines, Piperazines, Quinoxalines, Quinolones, Quinazolinones, Benzofuranes.
Chromatographic purification with ionic resins.
Micronization (third party partners).
Up to OEB4 Potency Level.

Chlorosulfonic acid
Sulfur trioxide
Pyridine
Ethylene oxide
Triphosgene
Hydrazine, Azides, Diphenyl-phosphorylazide, Acetyl Nitrate
Halogen chemistry:
Fluorine, chlorine, bromine, iodine
Hydrofluoric acid
Chlorine, chlorinating agents
Bromine, brominating agents (NBS, dibromohydantoin, phosphorous bromides)
Methylene diiodide, methyliodide, iodoform, TMSOZ

IPPC-based Authorization.
Integrated Pollution Prevention and Control.
Highly flexible and broad permit for all technologies, reagents and solvents.
Compliance with IED Directive 2010/75/UE.
Best Available Technology.
Compliance with Directive 105/15 2012/18/EU.
Seveso Directive.
Prevention and Control of On-Shore Major Accident Hazards involving Dangerous Substances.