About Archimica

We provide quality products and services, consistently,
reliably responsibly and continuously
applying some of the world’s
most difficult to handle chemical technologies.

Our independent one-site,
single entity corporate setup enables

Fast, direct
decisions

Simple, direct
decider access

Easiness to deal
with

Focus on customers
and business

History Lodi Site

1947
Foundation of Istituto Chemioterapico Italiano (I.C.I.)

1984
Foundation of Prime European Therapeuticals S.p.A (Euticals)

2008
Mandarin Capital Partners becomes majority Euticals shareholder

2012
Clessidra, an Italian Financial Fund becomes majority Euticals shareholder

2016
AMRI acquired Euticals Group

2019
Effective August 1, Livia acquires Lodi site, and brands it Archimica S.p.A.

Archimica Plant Lodi

Offering

Own products (APIs) for the generic pharmaceutical industry.
Synthesis: Manufacturing services and products for all user industries,
using Archimica´s highly differentiated setup and technologies

APIs, Building blocks, GMP intermediates, Regulatory Starting Materials

For all global markets including the United States of America,
in total Archimica products reach 25 countries.

Products

Technologies & Plant

Staff

64%

PRODUCTION

17%

QUALITY

12%

INFRASTRUCTURE

7%

BUSINESS & ADMINISTRATION

Plant

Equipment overview

Reactor Capacity: About 250 m3 (stainless steel and glass line).
Temperature Range: -20 to 150°.
Pressure Range: 10 mbar to 5 bar.
Reactor/Vessel Volume Range: 50 to 10.000 liter.
Dryers: Fluid bed dryer, agitated vacuum pan dryer, vacuum horizontal agitated dryer, vacuum double cone dryer, Planex® dryer, tray dryer.
Centrifuges: Vertical axis top discharge centrifuges, vertical axis bottom discharge centrifuges, horizontal axis peeler centrifuges.
Ancillary Equipment: Filter Press, Sieves, Filters, Ultra Filters.

Products plant list

F1 – QC Laboratory
F2A – Multi-Purpose Plant
F3A – Raw Materials, Intermediates and APIs warehouse
F3B – Finishing & Drying Plant (ISO 8, controlled environment)
F5A – Hydroxyurea Plant
F5B – Multi-Purpose Plant
F5C – Cytarabine Plant
F6A – Sucralfate Plant
F6B – Sulfamidics Plant
F7 – Multi-Purpose Plant
F8 – Utilities

Tech

Main differentiators

Highly flexible and broad permit for all technologies, reagents and solvents.
Broad range of extraordinary hazardous chemistry and chemicals processable in large scale:

  • solvents, including chlorinated and toxic solvents;

  • Strong acids including phosphorous oxychloride, chlorosulfonicacid, hydrofluoric acid;

  • Highly flammable, highly corrosive, explosive chemicals.

Residual thermal oxidizer allowing trace gas contamination removal, all waste gas streams.
Seveso guideline compliant.
Own on-site waste water treatment, backed by external partners.
Solvent recovery and tank farms.

Differentiators - Technology specialities

Large Scale Deacylated Phospholipids production (GPC, GPE)
Large Scale Use of Pyridine as reagent or solvent, as well as pyridine-SO3 complex handling.
Cytostatics manufacturing/drying:
Nucleosides.
Heterocyclic chemistry: Pyridines, Piperazines, Quinoxalines, Quinolones, Quinazolinones, Benzofuranes.
Chromatographic purification with ionic resins.
Micronization (third party partners).

Differentiators - Reagents & Solvents

Chlorosulfonic acid
Sulfur trioxide
Pyridine
Ethylene oxide
Triphosgene
Hydrazine, Azides, Diphenyl-phosphorylazide, Acetyl Nitrate
Halogen chemistry:

  • Fluorine, chlorine, bromine, iodine

  • Hydrofluoric acid

  • Chlorine, chlorinating agents

  • Bromine, brominating agents (NBS, dibromohydantoin, phosphorous bromides)

  • Methylene diiodide, methyliodide, iodoform, TMSOZ

Quality model

API Registration Form: AMA -26/2015
GMP Certificate: NBF/10/2015V

US-FDA
Last inspection April 2017

AIFA
Last Inspection July 2017

KFDA
Last inspection October 2011

Ministry of Health Veterinary
Last periodic inspection June 2019

Contacts

Site address
Viale Milano 86, 26900 Lodi (LO) Italy

Phone: +39 0371 49021
Fax: +39 0371 610019

GPS coordinates
Latitude: 45 °19’ 25,3“ N
Longitude: 9°27’ 57,7’’ E

The site is located in Northern Italy in Lombardia about 30 km South of Milano and Linate airport.
Access to the facility is the motorway A1 Milano-Bologna and the route SS9 Via Emilia.